Creatine phosphokinase (CPK) can be found mainly in the heart, brain, and skeletal muscle. CPK is made of three slightly different isoenzymes: CPK-1 (also called CPK-BB) is found mostly in the brain and lungs, CPK-2 (also called CPK-MB) is found mostly in the heart, and CPK-3 (also called CPK-MM) is found mostly in skeletal muscle. Therefore, by measuring CPK isoenzymes easily can tell which organ is injured.
On the other hand when the total CPK level is very high, it usually means there has been injury or stress to the heart, the brain, or muscle tissue. For example, when a muscle is damaged, CPK leaks into the bloodstream. Determining which specific form of CPK is high helps doctors determine which tissue has been damaged.
CPK can be used to diagnose MI, CVA, muscle damages, dermatomyositis, polymiositis, and muscle dystrophies. During each injury CPK is going to be raise after 5 to 6 hours after injury, it reaches to its maximum value after 18 to 24 hours and then it returns to normal value. The normal value for CPK is about 32 to 267 IU/L.
CPK is an enzyme that will rise in the blood as a result of injury to the brain, heart, or muscle tissues. In a person with high CPK level depending on which organ is getting involved, there may be a naturopathic treatment available. However, since raise in the CPK level along with the other blood tests such as LDH or SGPT is as a result of acute injury to an organ, therefore, most of the times conventional medical and monitoring will have priority to any other methods of treatments.